There are major fears that the very worst has happened after a Boeing 737 suddenly went missing after departing the Middle East.

Search and rescue operations are underway after a Boeing 737 suddenly went missing after departing the Middle East on Tuesday.

K2 Airways plane missing LIVE: Early flight data suggested the 27-year-old Boeing 737-400 freighter, operated by K2 Airways, may have crashed into the Arabian Sea southwest of Karachi after a series of sharp altitude changes followed by a steep final descent.

A Boeing 737 cargo plane operated by Pakistan's K2 Airways went missing over the Arabian Sea after reporting navigational issues. Search and rescue efforts are ongoing with military involvement.

The chilling final message sent by the pilots on board the missing K2 Airways Boeing 737 cargo plane has been revealed. The plane, which took off from Sharjah, UAE, was heading to its final destination of Karachi,

A search and rescue operation is underway as a Boeing 737 cargo plane carrying five people disappeared from radar around Pakistan