Reactive oxygen species (ROS) produced naturally during cellular metabolism often cause oxidative damage to cells. However, these molecules also play an important role in normal cellular signaling.

To function normally, nearly every cell in the human body relies on G-protein coupled receptors (GPCRs) to receive and send ...

For the immune system to effectively combat pathogens, antibody responses must be precisely controlled. So-called follicular ...

In a recently published review, a research team led by MedUni Vienna has highlighted a promising new approach to drug discovery. The focus is on the targeted modulation of certain intracellular ...

Phosphoinositides are a family of membrane lipids distinguished by phosphate groups at specific positions on the inositol ring, acting as spatial and temporal organisers of cell activity. Through ...

Phospholipase C (PLC) enzymes constitute a pivotal hub in cellular signalling by hydrolysing the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP₂) to generate the second messengers ...

Researchers at Texas A&M Health and collaborators have developed engineered CRAC channel inhibitory binders that can ...

BPC-157 and TB-500, originating from gastric and thymic sources respectively, both influence angiogenesis, cytoskeletal ...

Omaveloxolone (approved for Friedreich's ataxia) may help protect cells from stress and correct underlying dysfunction in SMA ...