A new statistical framework could speed up the search for rare mutations that cause common diseases, helping researchers zero ...

Researchers have been trying to solve the mystery of a rare genetic disorder called spinocerebellar ataxia 4 (SCA4) for many years. The disease causes impairments in movement and balance, and these ...

Scientists from the University of Nottingham have developed a new method of genetic analysis, which extracts more precise data than previously used methods when looking at DNA, and will improve our ...

There are individuals who carry the same deletion of chromosome 16, and those same delections can lead to a wide range of potential neurodevelopmental issues in carriers, from milder mental illnesses ...

The study of ancient DNA is demonstrating how genetic ancestry can sculpt disease risk. Barrie et al. investigated the genetic provenance of multiple sclerosis (MS); a neurodegenerative auto-immune ...

The expansion of ancestrally diverse genetic cohorts has altered the landscape of complex disease genetics. Differences in linkage disequilibrium across populations have improved fine-mapping and the ...

Deep learning models have shown great potential in predicting and engineering functional enzymes and proteins. Does this prowess extend to other fields of biology as well? Contrary to expectations, a ...

A UNIGE team has discovered the genetic programs that allow motor neurons to retract from the spinal cord. This discovery opens up prospects for combating neurodegeneration. Neuroscientists at the ...

Predicting observable traits from genetic variation remains difficult due to the complex interplay of multiple genes and environmental influences. Widely used statistical approaches are limited in ...

Genome assemblies from 65 individuals, representing a variety of the world’s populations, are advancing the scientific exploration of complex genetic structural variation. Structural variations are ...

Sweet potatoes are an agricultural powerhouse that feeds millions globally. However, their complex genetics make it challenging for breeders to understand and improve traits like yield, disease ...