Missing DNA replication step revealed in first image of pre-initiation complex

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...
Phys.org

DNA replication in early embryos differs from previous assumptions, study shows

A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues, the ...
Nature

Inferring replication timing and proliferation dynamics from single-cell DNA sequencing data

Dysregulated DNA replication is a cause and a consequence of aneuploidy in cancer, yet the interplay between copy number alterations (CNAs), replication timing (RT) and cell cycle dynamics remain ...
Nature

Enhancing transcription–replication conflict targets ecDNA-positive cancers

The alternative text for this image may have been generated using AI. Fig. 3: RS activated S-phase checkpoint and generated vulnerability to CHK1 inhibition in ecDNA-containing tumour cells. The ...