The syndrome of normal pressure hydrocephalus (NPH) was first described by Adams et al. almost 60 years ago, in patients with a classical clinical triad of ataxia, incontinence and dementia 1. These ...

Biomedical engineers at Duke University have developed a technique to noninvasively visualize the brain's waste-removal ...

Apathy is frequently observed in idiopathic normal pressure hydrocephalus (iNPH) and worsens cognitive impairment and gait disturbance. In this study, we evaluated the regions associated with apathy ...

The typical signs and symptoms of idiopathic NPH are shown. In a retrospective study involving 418 patients with shunt-responsive idiopathic NPH, 96% of the patients had gait difficulty, 76% had ...

Cerebrospinal fluid (CSF) and other biomarkers differ for individuals with Alzheimer disease and cognitively normal controls, with the estimated times of divergence varying from 18 to six years before ...

Researchers report that the flow of cerebrospinal fluid in the brain is linked to waking brain activity. The study demonstrates that manipulating blood flow in the brain with visual stimulation ...

Research headed by teams at the University of Rochester Center for Translational Medicine and the University of Copenhagen describes for the first time how a spreading wave of disruption and the flow ...

Few scientists doubt that backed-up clearance of detritus from the brain correlates with accumulation of amyloid plaques and neurofibrillary tangles. But which comes first? Data presented at the 9th ...

New neuroimaging research shows that when sleep-deprived people lose focus, the brain briefly shifts toward sleep-like physiology, offering fresh insight into why cognitive performance declines ...