All biological systems are to some extent evolvable. That is, they are capable of bringing forth variation that is both adaptive and heritable, and that enables them to respond to natural selection.

Mutations in isocitrate dehydrogenase (IDH) are frequently found in low-grade gliomas, secondary glioblastoma, chondrosarcoma, acute myeloid leukemias, and intrahepatic cholangiocarcinoma. However, ...