For the first time ever, scientists are attempting to reverse cellular aging in a living patient. The target: incurable ...

Test time has arrived: the first person has been treated in a highly anticipated gene therapy trial that aims to coax aged cells to take on a younger identity. The clinical trial will test a novel ...

A newly identified molecule called OLE helped restore the brain’s immune cells to a more protective state in Alzheimer’s ...

Promising mouse studies and billions of dollars in funding are stoking excitement. But we’ve been here before.

EPFL researchers have uncovered how transcription factor dosage reshapes cell identity, showing that even small differences in dose can steer cells toward completely different fates. Their findings ...

Aging, at its most fundamental level, is a molecular process. Chemical marks on the genome shift and lose fidelity over time, ...

A team led by researchers has discovered that a group of cells located in the skin and other areas of the body, called neural crest stem cells, are the source of reprogrammed neurons found by other ...

Manipulating cell identity through transcription factor-mediated reprogramming, induced pluripotency or directed differentiation holds promise for disease modelling and regenerative medicine. Yet the ...

Researchers at Oregon Health & Science University have uncovered a key reason why immunotherapy has largely failed in pancreatic cancer—and identified a promising strategy to overcome that resistance.

A man who was fully paralyzed is now able to stand after receiving an injection of reprogrammed stem cells into his injured spinal cord. The result, announced by researchers in Japan, marks a rare and ...

Cell therapy, particularly using cardiomyocytes, shows significant promise for treating heart failure. Direct reprogramming of somatic cells into cardiomyocytes using small molecules is advantageous ...

Leuven, 11 March 2025 – Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center ...