Structured illumination microscopy (SIM) is the most preferable system for live-cell super-resolution imaging. It enables the observation of intricate subcellular dynamics. However, conventional SIM ...

Parallel acquisition-readout structured-illumination microscopy (PAR-SIM) was designed for high-speed raw data acquisition. By utilizing an xy-scan galvo mirror set, the raw data is projected onto ...

As a researcher interested in the architecture and organization of neurons within mammalian brains, Christophe Leterrier, a neuroscientist at the French National Centre for Scientific Research-Aix ...

Even those who maintain that super-resolution microscopy is a powerful tool of biological discovery have admitted that it may have a bit of an image problem. For example, in a recent review, several ...

To unravel the complexities of biological phenomena, scientists have long relied on microscopy to visualize the intricate details of their specimens, including tissue architecture, cell morphology, ...

Blind structured illumination microscopy (blind-SIM) is a valuable tool for achieving super-resolution without the need for known illumination patterns. However, in its current formulation the ...

When single-molecule super-resolution microscopes were first commercialized some 15 years ago, they made headlines for their ability to resolve individual molecules and structures at the nanometer ...

Today's super-resolution microscopes have made it possible to observe the nanoscale world with unprecedented detail. However, they require fluorescent tags, which reveal structural details but provide ...

Peking University, Aug 18, 2025: Professor Xi Peng’s team from the College of Future Technology at Peking University has recently developed a triangle structured illumination microscopy (SIM), which ...

SIMIP enables high-resolution images rich in both chemical and spatial information. A quantum cascade laser (QCL) excites molecular vibrations while a spatial light modulator (SLM) generates striped ...