Methods for depth normalization have been assessed primarily with simulated data or cell-line–mixture data. There is a pressing need for benchmark data enabling a more realistic and objective ...

The rapid evolution of mass spectrometry (MS) has transformed biological research, yet the reliability of these insights depends entirely on the rigor of the applied proteomics statistics.

RNA-Seq and gene expression microarrays provide comprehensive profiles of gene activity, but lack of reproducibility has hindered their application. A key challenge in the data analysis is the ...