Structure determines function. The discovery of the DNA double-helix structure revealed how genetic information is stored and copied. In the mammalian cell nucleus, up to two meters of DNA is ...
Visualizing the repair of broken DNA in living cells reveals a new mechanism for DNA homology search
We engineered a tagged version of the yeast Rad51 recombinase and used this tool to monitor DNA double-strand break repair in living cells. We could observe how a broken DNA fragment can scout the ...
Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...
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