Promising mouse studies and billions of dollars in funding are stoking excitement. But we’ve been here before.

Researchers are decoding how signals move between body and brain, with implications for how we understand and treat ...

South Korean researchers have identified a new therapeutic target that could help overcome the limitations of anti-angiogenic ...

Signal transduction and gene regulation are at the heart of cell and developmental biology, driving cell fate decisions and tissue homeostasis. In cancer, ...

Contributed by Myles Brown, November 6, 2019 (sent for review July 9, 2019; reviewed by Douglas Yee and Wilbert Zwart) In this study, we integrated FOXA1 cistrome, epigenetic histone marks, and ...

Objective Dysregulated cellular metabolism is a distinct hallmark of human colorectal cancer (CRC). However, metabolic programme rewiring during tumour progression has yet to be fully understood.

CTBs give rise to multinucleated STBs through the cell–cell fusion procedure (also termed trophoblast syncytialization). Localized at the outer layer of the villus, the STBs contribute to substance ...

These pathways involve metabolic reprogramming, proliferation signaling, EMT, immune evasion, and therapy resistance, with PFK at the center of cancer cell metabolism and malignant behavior. This ...

Single-Cell Cross-Modal Transfer by Adversarial Fine-Tuning of Foundation Models Joseph Boyd , Matthew Lyon , Martino Mansoldo , Christian Hurry , Finnian Firth Critic-Guided Heterogeneous Multi-Agent ...