The brain encodes the statistical regularities of the environment in a task-specific yet flexible and generalizable format. Here, we seek to understand this process by bridging two parallel lines of ...

Vascular smooth muscle cells (VSMCs) phenotype switch from contractile to proliferative phenotype is a pathological hallmark in various cardiovascular diseases. Recently, a subset of long noncoding ...

Protein Kinase A (PKA) is an essential kinase that is conserved across eukaryotes and plays fundamental roles in a wide range of organismal processes, including growth control, learning and memory, ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Single-target quantitative polymerase chain reaction (qPCR) is ...

G-protein-coupled-receptor (GPCR) signaling is exquisitely controlled to achieve spatial and temporal specificity. The endogenous protein kinase inhibitor peptide (PKI) confines the spatial and ...

Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, United States Engineering Research Center for Biorenewable Chemicals, Iowa State ...

Genome editing is a set of methods used to change the DNA of a cell with single base-pair precision. It is a specific form of gene therapy, and the engineering of cells through genome editing has the ...

Decreased hippocampal-prefrontal synchrony may mediate cognitive deficits in schizophrenia but it remains unclear which cells orchestrate this long-range synchrony. Parvalbumin- (PV) and ...

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Is the human mind/brain composed of a set of highly specialized components, each carrying out a specific aspect of human cognition, or is it more of a general-purpose device, in which each component ...