Innovative algorithm makes genomic surveillance faster and more affordable for global disease outbreaks

Genomic surveillance—the process of monitoring and sequencing pathogens—is one of the most important tools for detecting ...
eLife

Deciphering interferon functions in avian influenza using receptor knockout models in the natural host

Interferon receptor knockout chickens uncover how type I and III interferons differentially shape avian antiviral immunity and influenza disease outcomes.
Lupus Science & Medicine

Prognostic value of baseline clinical features in SLE: a cluster analysis

Objective SLE is a heterogeneous systemic autoimmune disease with diverse clinical manifestations. We aimed to identify clinical subgroups of SLE patients using cluster analysis at diagnosis and at ...
BMJ

Prediction of radiographic progression in rheumatoid arthritis and the role of antibodies against mutated citrullinated vimentin: results from a 10-year prospective study

Objectives: Anti-citrullinated peptide antibodies (ACPAs) are established as useful predictors of radiographic progression in rheumatoid arthritis (RA). The main objective of this study was to test ...
snmjournals.org

Striatal Dopamine Transporter Availability Associated with Polymorphisms in the Dopamine Transporter Gene SLC6A3

Polymorphisms in the gene SLC6A3 for the dopamine transporter (DAT) have been associated with DAT availability in the human brain. This finding suggests an effect of these polymorphisms, or of ...
BMJ

Differentiation between athlete’s heart and dilated cardiomyopathy in athletic individuals

Objective Distinguishing early dilated cardiomyopathy (DCM) from physiological left ventricular (LV) dilatation with LV ejection fraction <55% in athletes (grey zone) is challenging. We evaluated the ...
Frontiers

Identification of core genes in intervertebral disc degeneration using bioinformatics and machine learning algorithms

Gene expression profiles, including those from 35 LDH patients and 43 healthy volunteers, were downloaded from the GEO database (GSE124272, GSE150408, GSE23130, GSE153761). After merging four ...
Europe PMC

Identification and analysis of key genes in adipose tissue for human obesity based on bioinformatics.

Obesity is a complex condition that is affected by a variety of factors, including the environment, behavior, and genetics. However, the genetic mechanisms underlying obesity remains poorly elucidated ...
BMJ

Randomised double-blind controlled trial of non-invasive preimplantation genetic testing for aneuploidy in in vitro fertilisation: a protocol paper

Introduction The success rate of in vitro fertilisation (IVF) treatment for couples with infertility remains low due to lack of a reliable tool in selecting euploid embryos for transfer. This study ...
The Lancet

Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study

aNational Institute of Diabetes and Digestive and Kidney Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA bSurgical Oncology Program, National Cancer Institute, ...
PNAS

A Bayesian switching linear dynamical system for estimating seizure chronotypes

Dynamical systems have been used to model the paroxysmal nature of seizures in epilepsy. In parallel, seizures have been discovered to occur with cyclical periodicity in epilepsy, occurring at ...