Ras-dependent activation of RAF and ERK1/2 contributes to cytoskeletal remodeling and neuronal migration in the developing brain. In parallel, PI3K-mediated phosphorylation of Akt promotes mTOR ...
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Loss of SNORD50A and SNORD50B increased the amount of GTP-bound, active K-Ras and hyperactivated Ras-ERK1/ERK2 signaling. Given RAS pathway alterations in pediatric neuroblastoma (ALK mutations), ...
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