Hidden pocket reveals new way to target prostate cancer's 'undruggable' ERG protein

In the United States, prostate cancer is a leading cause of cancer-related disease and death in men. About half of prostate ...
IEEE

CoIn: Correlation Induced Clustering for Cognition of High Dimensional Bioinformatics Data

Abstract: Analysis of high dimensional biomedical data such as microarray gene expression data and mass spectrometry images, is crucial to provide better medical services including cancer subtyping, ...
Nanowerk

Microarray Definition: How DNA Microarrays Work, Types, and Uses

Definition: A microarray is a small, flat substrate carrying an ordered grid of microscopic probe features, each containing a known biological molecule, that is used to measure many molecular targets ...
gut.bmj

Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression

Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands Department of Gastroenterology, VU University Medical Center, Amsterdam, The Netherlands Dr G A Meijer, Department of ...
gut.bmj

A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise

1 Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan 2 Department of Molecular Gastroenterology and Hepatology, Kyoto ...
Medscape

Trop-2 Protein Overexpression is an Independent Marker for Predicting Disease Recurrence in Endometrioid Endometrial Carcinoma

Background Endometrial cancer is the most common gynecologic malignancy in developed countries. Trop-2 is a glycoprotein involved in cellular signal transduction and is differentially overexpressed ...
thorax.bmj

Identification of eight-protein biosignature for diagnosis of tuberculosis

Background Biomarker-based tests for diagnosing TB currently rely on detecting Mycobacterium tuberculosis (Mtb) antigen-specific cellular responses. While this approach can detect Mtb infection, it is ...
ahajournals.org

LncRNA PSR Regulates Vascular Remodeling Through Encoding a Novel Protein Arteridin

Vascular smooth muscle cells (VSMCs) phenotype switch from contractile to proliferative phenotype is a pathological hallmark in various cardiovascular diseases. Recently, a subset of long noncoding ...
ahajournals.org

SPARC, a Novel Regulator of Vascular Cell Function in Pulmonary Hypertension

Pulmonary hypertension (PH) is a life-threatening disease, characterized by excessive pulmonary vascular remodeling, leading to elevated pulmonary arterial pressure and right heart hypertrophy. PH can ...
Frontiers

Global Screening of LUBAC and OTULIN Interacting Proteins by Human Proteome Microarray

Linear ubiquitination is a reversible posttranslational modification, which plays key roles in multiple biological processes. Linear ubiquitin chain assembly complex (LUBAC) catalyzes linear ...
ascopubs.org

A phase I study of safety and immunogenicity of survivin long peptide vaccine (SurVaxM) in patients (pts) with metastatic neuroendocrine tumors (NETs).

Incidence and patterns of secondary malignancies in patients with neuroendocrine neoplasms: A SEER database analysis. Background: Metastatic neuroendocrine tumors (NETs) have a poor prognosis and ...
IEEE

Surface Modification for Protein and DNA Immobilization onto GMR Biosensor

Abstract: Giant magnetoresistance (GMR) biosensor with 20 nm SiO 2 on surface was successfully modified by 3-aminopropyltriethoxy silane (APTES) and glutaraldehyde (Glu). The resultant functionalized ...