A method for arrayed CRISPRi screening in organoids enables the investigation of morphogenesis in human stem cell-derived tissues, revealing the roles of ZIC2, SOX11, and ZNF521 in neural tube closure ...

An imbalance between energy intake and expenditure represents the main cause of obesity and is associated with various metabolic conditions, including non-alcoholic fatty liver disease, metabolic ...

Active zones at chemical synapses are highly specialized sites for the regulated release of neurotransmitters. Despite a high degree of active zone protein conservation in vertebrates, every type of ...

The behavior of steel structures subjected to seismic actions depends directly on the connections behavior. There are two current tendencies for ensuring the structural ductility: allowing the ...

Synaptic pruning in primate prefrontal cortical circuitry has been proposed to contribute to working memory maturation. However, pruning of excitatory synapses has only been shown on pyramidal neurons ...

The frequent cross-talk between neighbouring genes observed in our study indicates that gene loci can encode multiple independent categories of functions. Category I involves functions of the RNA ...

Here we present an exception that supports the rule that the 20 human tRNA synthetases acquired new architectures to expand their functions during evolution. The new features are associated with novel ...

Architecturally exposed structural steel (AESS) is a mix of art, science and know-how, introducing the issue of ‘personal preference’ for what is considered aesthetically-pleasing, while remaining ...