C&EN

Covalent Targeting Leads to the Development of a LIMK1 Isoform-Selective Inhibitor

Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany Structure Genomics Consortium Buchmann Institute for Molecular Life ...
Frontiers

WhiA transcription factor provides feedback loop between translation and energy production in a genome-reduced bacterium

WhiA is a conserved protein found in numerous bacteria. It consists of an HTH DNA-binding domain linked with a homing endonuclease (HEN) domain. WhiA is one of the most conserved transcription factors ...
C&EN

Evaluation of an Affinity-Enhanced Anti-SARS-CoV2 Nanobody Design Workflow Using Machine Learning and Molecular Dynamics

Hevesy György PhD School of Chemistry, Institute of Chemistry, Eötvös Loránd University, Budapest, Pázmány Péter sétány. 1/A, Budapest H-1117, Hungary Laboratory of Structural Chemistry and Biology, ...
Europe PMC

Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases.

Abortive infection (Abi) is a bacterial antiphage defense strategy involving suicide of the infected cell. Some Abi pathways involve polymerases that are related to reverse transcriptases. They are ...
PNAS

Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer

Hepatitis C virus infects 1% of the world’s population, with no vaccine currently available. One vaccine candidate is the membrane-associated E1E2 envelope glycoprotein which has been used in clinical ...
PNAS

The KaiA protein of the cyanobacterial circadian oscillator is modulated by a redox-active cofactor

The circadian rhythms exhibited in the cyanobacterium Synechococcus elongatus are generated by an oscillator comprised of the proteins KaiA, KaiB, and KaiC. An external signal that commonly affects ...