In the study of bacteria, a longstanding dogma has held that two molecular machines—RNA polymerase, which leads the way in transcribing DNA into RNA, and ribosomes, which bring up the rear translating ...

DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave. Researchers have now mapped this hidden architecture in unprecedented detail, showing ...

A new study has uncovered a previously overlooked hotspot for mutations at the starting points of human genes. These regions mutate far more often than expected, especially during the earliest stages ...

Researchers have discovered new regions of the human genome particularly vulnerable to mutations. These altered stretches of DNA can be passed down to future generations and are important for how we ...

The Genomics Primer serves as a foundation for practitioners to reference for basic definitions and concepts in the field of genomic medicine. Upon successful completion of this module, participants ...

DNA is a biological molecule that contains the instructions an organism needs to function, develop, and reproduce. It is present in all forms of life on earth and contains each organism’s genetic code ...

Ring-shaped extrachromosomal DNA is implicated in many cancers. Rachel Brazil talks to the scientists trying to uncover their secrets Article summary Discovery and prevalence: ecDNA, first observed in ...

Researchers have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and premature aging. Researchers at ...

Mirin, the chemical inhibitor of MRE11, has been recently reported to prevent immune response activation caused by mitochondrial DNA (mtDNA) breakage and release upon replication stalling. We show ...

Circular single-stranded DNA viruses of the family Geminiviridae encode replication-associated protein (Rep), which is a multifunctional protein involved in virus DNA replication, transcription of ...

DNA has become a popular choice for next-generation storage media due to its high storage density and stability. As the storage medium of life’s information, DNA has significant storage capacity and ...

Although both forms of nucleic acid use a four-letter alphabet that includes A, C and G, DNA uses T, whereas RNA uses U. However, it's a relatively trivial difference, as T and U are read as ...