Germany expands its missile defence network with a second Arrow-3 site planned in the southern province of Bavaria, extending ...

J.B. Maverick is an active trader, commodity futures broker, and stock market analyst 17+ years of experience, in addition to 10+ years of experience as a finance writer and book editor. David ...

Geographic atrophy (GA) is a severe form of age-related macular degeneration with limited treatment options, affecting millions worldwide. Recent FDA-approved therapies, pegcetacoplan and avacincaptad ...

This fundamental study significantly advances our understanding of how parasites evade the host complement immune system. The new cryo-EM structure of the trypanosome receptor ISG65 bound to ...

Human C-reactive protein (CRP) activates the complement system to protect us from infections, but can also contribute toward progression of cardiovascular and autoimmune diseases when misactivated.

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Article Views are the COUNTER-compliant sum of full text article downloads since ...

The components of blood include plasma, platelets, and red and white blood cells that circulate through the body. Blood supplies essential substances, such as sugars and oxygen, to cells and organs, ...

1 The name of the complement receptor used in this review appears in bold. Alternative names and CD nomenclature (if available) are also indicated. 2 Main (canonical) ligands are given first. Other ...

The innate immune system is the first line of host defense against infection and is comprised of humoral and cellular mechanisms that recognize potential pathogens within minutes or hours of entry.

Complement is an essential component of innate immunity. Its activation results in the assembly of unstable protease complexes, denominated C3/C5 convertases, leading to inflammation and lysis.

Binding of the complement-downregulating protein factor H (fH) to the surface of the meningococcus is important for survival of the organism in human serum. The meningococcal vaccine candidate factor ...