A 1,563‑sample chromatin atlas reveals 16 epigenomic subgroups of AML, redefining disease classification, prognosis, and therapeutic vulnerabilities.

A Cornell-led study is challenging a decades-old explanation for how chromosomes exchange genetic material within the ...

Chronic and viral infections can literally exhaust certain key cells in the immune system from a constant barrage of attacks.

Blood-based DNA repair and stress-response signals reveal a brief molecular window preceding Parkinson’s diagnosis. Study: Longitudinal assessment of DNA repair signature trajectory in prodromal ...

Model of ET-regulated anthocyanin biosynthesis via the LvMYB5-LvERF113-LvMYB1 module in ‘Viviana’ lilies. Dashed boxes represent the regulatory links speculated based on the literature and the thick ...

Gene editing is a form of genetic modification and is the process by which the DNA sequence of an organism is modified or deleted. This is normally carried out to obtain desirable effects, such as the ...

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Xeroderma pigmentosum (XP) is a rare genetic condition in which exposure to sunlight leads to a high tumor incidence due to defective DNA repair machinery. Herein, we investigated seven patients ...

Hantaviruses are RNA viruses with known epidemic threat and potential for emergence. Several rodent-borne hantaviruses cause zoonoses accompanied by severe illness and death. However, assessments of ...

Autophagy is the major intracellular degradation route in mammalian cells. Systemic ablation of core autophagy-related (ATG) genes in mice leads to embryonic or perinatal lethality, and conditional ...

It has been well established that leukemia inhibitory factor (LIF) is essential for maintaining naïve pluripotency of embryonic stem cells (ESCs). Oncostatin M (OSM) is a member of the IL-6 family of ...