Chronic inflammation initiated by inflammatory monocytes underlies the pathogenesis of atherosclerosis. However, approaches that can effectively resolve chronic low-grade inflammation targeting ...

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Non-small-cell lung cancer (NSCLC) is the poster child of personalized medicine. With increased knowledge about biomarkers and the consequent improvement in survival rates, NSCLC has changed from ...

aDepartment of Science and Technology-National Research Foundation (DST-NRF) Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University ...

Which genes and gene signaling pathways mediate regenerative processes? In recent years, multiple studies, using a variety of animal models, have aimed to answer this question. Some answers have been ...

High-affinity antibodies that protect us from infection are produced by B cells through an evolutionary process of mutation and selection during adaptive immune responses. B cell repertoire sequencing ...

Biomarker testing is necessary for determining the optimal treatment of patients newly diagnosed with NSCLC. Practical guidelines such as the CAP/IASLC/AMP, ASCO, and National Comprehensive Cancer ...

DNA methylation is a vital epigenetic mechanism by which gene expression is promoted or inhibited. It occurs at crucial steps in development, as well as in a number of disease states. DNA methylation ...

High-throughput sequencing methods are revolutionizing biology and promise to substantally impact the future of medicine. However, reductions in cost and improvements in turnaround time and sample ...

There have been rapid recent developments in establishing methods for identifying and characterising viruses associated with animal and human diseases. These methodologies, commonly based on ...

The outcomes of gene therapy to correct congenital immunodeficiencies are unknown. We reviewed long-term outcomes after gene therapy in nine patients with X-linked severe combined immunodeficiency ...