BMJ

Metabolic phenotyping and cardiovascular disease: an overview of evidence from epidemiological settings

Metabolomics, the comprehensive measurement of low-molecular-weight molecules in biological fluids used for metabolic phenotyping, has emerged as a promising tool to better understand pathways ...
PNAS

Lipid raft proteomics identify endothelial myosin-9 (MYH9) as a regulator of low-density lipoprotein transcytosis and atherosclerosis

Transcytosis of Low-Density Lipoprotein (LDL) across the arterial endothelium is an essential early step in atherosclerosis. Little is known about its regulation. Mass spectrometry of ...
The Lancet

Characterisation of pregnancy-induced alterations in apolipoproteins and their associations with maternal metabolic risk factors and offspring birth outcomes: a preconception ...

gDepartment of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore ...
C&EN

Effect of Delayed Centrifugation on the Levels of NMR-Measured Lipoproteins and Metabolites in Plasma and Serum Samples

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim 7491, Norway K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and ...
GitHub

* CHOLMOD/Include/cholmod_core.h.

* Lesser General Public License. See lesser.txt for a text of the license. * CHOLMOD is also available under other licenses; contact authors for details. /* CHOLMOD Core module: basic CHOLMOD objects ...
Europe PMC

Hypoxia inducible factor 1α inhibitor PX-478 reduces atherosclerosis in mice.

Hypoxia inducible factor 1α (HIF1α) plays a critical role in atherosclerosis as demonstrated in endothelial-targeted HIF1α -deficient mice. However, it has not been shown if specific pharmacological ...
ahajournals.org

Endothelial HMGB1 Is a Critical Regulator of LDL Transcytosis via an SREBP2–SR-BI Axis

LDL (low-density lipoprotein) transcytosis across the endothelium is performed by the SR-BI (scavenger receptor class B type 1) receptor and contributes to atherosclerosis. HMGB1 (high mobility group ...
ahajournals.org

Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation

Atherosclerosis is driven by synergistic interactions between pathological, biomechanical, inflammatory, and lipid metabolic factors. Our previous studies demonstrated that absence of caveolin-1 (Cav1 ...
C&EN

Toward Reliable Lipoprotein Particle Predictions from NMR Spectra of Human Blood: An Interlaboratory Ring Test

Lipoprotein profiling of human blood by 1 H nuclear magnetic resonance (NMR) spectroscopy is a rapid and promising approach to monitor health and disease states in medicine and nutrition. However, ...
Europe PMC

A Quantitative Systems Pharmacology Platform to Investigate the Impact of Alirocumab and Cholesterol-Lowering Therapies on Lipid Profiles and Plaque Characteristics.

Reduction in low-density lipoprotein cholesterol (LDL-C) is associated with decreased risk for cardiovascular disease. Alirocumab, an antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), ...
Nature

Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells

Atherosclerotic cardiovascular disease is the leading cause of death worldwide. The development of atherosclerosis is triggered by the subendothelial retention of plasma-derived apoB-lipoproteins, ...