aFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK bFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, ...
dBarts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK eDepartment of Infection, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK fDepartment of Virology, St ...
Coronavirus (CoV) spillover events from wildlife reservoirs can result in mild to severe human respiratory illness. These spillover events underlie the importance of detecting known and novel CoVs ...
Neuromuscular and neurodegenerative diseases are mostly modeled using genetically modified animals such as mice. However, animal models do not recapitulate all the phenotypes that are specific to ...
Crimean-Congo haemorrhagic fever (CCHF) is a widespread tickborne disease that circulates in wild and domestic animal hosts, and causes severe and often fatal haemorrhagic fever in infected humans.
Cell death activates different intracellular enzymes, such as lipases, proteases, and nucleases. Lysosomes, that contain hydrolytic enzymes, can break down biomolecules like histone proteins. The ...
DNA methylation is an important epigenetic process which has diverse roles to regulate gene expression, imprinted genes, inactivation of X chromosomes, and the dysregulation of these patterns in ...
The investigational 9-valent viruslike particle vaccine against human papillomavirus (HPV) includes the HPV types in the quadrivalent HPV (qHPV) vaccine (6, 11, 16, and 18) and five additional ...
DNA polymerases have evolved for billions of years to accept natural nucleoside triphosphate substrates with high fidelity and to exclude closely related structures, such as the analogous ...