ahajournals.org

Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial ...

Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) is an effective therapy for reducing low-density lipoprotein (LDL) cholesterol (LDL-C) in adults with hyperlipidemia, including ...
The Lancet

COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis

aDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA bDepartment of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA ...
Frontiers

Identification of key genes modules linking diabetic retinopathy and circadian rhythm

Diabetic retinopathy (DR) is a leading cause of vision loss worldwide. Recent studies highlighted the crucial impact of circadian rhythms (CR) on normal retinopathy in response to the external light ...
PNAS

Yeast PIC-mediator structure with RNA polymerase II C-terminal domain

At gene promoters, RNA polymerase II (Pol II) assembles into a preinitiation complex (PIC) which includes the coactivator Mediator. Here, we describe the PIC-Mediator complex from yeast at ...
Frontiers

Dynamic Alternative Splicing During Mouse Preimplantation Embryo Development

The mechanism of alternative pre-mRNA splicing (AS) during preimplantation development is largely unknown. In order to capture the dynamic changes of AS occurring during embryogenesis, we carried out ...