Compounds targeting microtubules are widely used in cancer therapy with a proven efficacy. However, because they also target non-cancerous cells, their administration leads to numerous adverse effects ...
Mammalian reovirus (reovirus), prototype member of the Reoviridae family, is characterized by transcription of the dsRNA genome within the innermost capsid shell. Here, we report five in situ ...
Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site
Natural products provide the inspiration for most drugs, and marine natural products, in particular, are emerging as promising new therapeutics with new targets or mechanisms of action.
† Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K. ‡ Medicinal Chemistry, Department of Pharmacy and Pharmacology, ...
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results