Hidden pocket reveals new way to target prostate cancer's 'undruggable' ERG protein

In the United States, prostate cancer is a leading cause of cancer-related disease and death in men. About half of prostate ...

New CRISPR method makes it possible to control protein production in cells

The speed at which a cell produces proteins is a decisive factor in determining whether it divides, specializes or retains ...
Nature

Chronic Hypoxia and Rat Lung Development: Analysis by Morphometry and Directed Microarray

It is unclear how sublethal hypoxia affects lung development. To investigate the effects of chronic hypoxia on postnatal lung remodeling, we treated neonatal rats with FIO 2 of 0.12 for 10 d and ...
C&EN

Screening Bicyclic Peptide Libraries for Protein–Protein Interaction Inhibitors: Discovery of a Tumor Necrosis Factor-α Antagonist

† Department of Chemistry and Biochemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, United States ‡ Center for Perinatal Research, The Research Institute at Nationwide ...