New adenomyosis atlas reveals lesion-specific signals that may spare healthy uterine tissue

Researchers at the University of Liverpool have identified distinctive biological characteristics within adenomyosis lesions ...
SciELO

A conceptual and practical overview of cDNA microarray technology: implications for basic and clinical sciences

cDNA microarray is an innovative technology that facilitates the analysis of the expression of thousands of genes simultaneously. The utilization of this methodology, which is rapidly evolving, ...
ascopubs.org

Decipher score as a predictor of response to treatment intensification in the NRG Oncology-RTOG 0534 (SPPORT) phase III randomized post-prostatectomy salvage radiotherapy trial.

Prognostic significance of tumor immune microenvironment dynamics in prostate cancer induced by androgen deprivation therapy. Impact of specimen type on digital histopathology-based multimodal ...
C&EN

Microarray-Based Methodology for Lipid Profiling, Enzymatic Activity, And Binding Assays in Printed Lipid Raft Membranes from Astrocytes and Neurons

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Lipid rafts are liquid-ordered domains in which specific enzymes and receptors are ...
gut.bmj

DNA-methylation signature accurately differentiates pancreatic cancer from chronic pancreatitis in tissue and plasma

Objective Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Differentiation from chronic pancreatitis (CP) is currently inaccurate in about one-third of cases. Misdiagnoses in both ...
Europe PMC

Identification and analysis of key genes in adipose tissue for human obesity based on bioinformatics.

Obesity is a complex condition that is affected by a variety of factors, including the environment, behavior, and genetics. However, the genetic mechanisms underlying obesity remains poorly elucidated ...
The Lancet

Adipose tissue cysteine dioxygenase type 1 is associated with an anti-inflammatory profile, impacting on systemic metabolic traits

aDepartment of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IdIBGi), CIBEROBN (CB06/03/010), 17190 Salt, Spain bCIBER de la Fisiopatología de la Obesidad y ...
C&EN

Optimization of an Antibody Microarray Printing Process Using a Designed Experiment

Center for Applied NanoBioscience and Medicine, College of Medicine, University of Arizona, Phoenix, Arizona 85004, United States Department of Basic Medical Sciences, The University of Arizona, ...
Frontiers

Cytokine Activation Reveals Tissue-Imprinted Gene Profiles of Mesenchymal Stromal Cells

Development of standardized metrics to support manufacturing and regulatory approval of mesenchymal stromal cell (MSC) products is confounded by heterogeneity of MSC populations. Many reports describe ...
Frontiers

Gene Expression Profiles Analyzed Using Integrating RNA Sequencing, and Microarray Reveals Increased Inflammatory Response, Proliferation, and Osteoclastogenesis in Pigmented ...

Pigmented villonodular synovitis (PVNS) is a rare condition that involves benign proliferation of the synovial tissue and is characterized by severe joint destruction and high recurrence even after ...
eLife

Miniaturized 3D bone marrow tissue model to assess response to Thrombopoietin-receptor agonists in patients

Platelets are tiny cell fragments essential for blood to clot. They are created and released into the bloodstream by megakaryocytes, giant cells that live in the bone marrow. In certain genetic ...
ahajournals.org

Perivascular Adipose Tissue Inflammation in Ischemic Heart Disease

There is growing recognition that adipose tissue–derived proatherogenic mediators contribute to obesity-related cardiovascular disease. We sought to characterize regional differences in perivascular ...