annotate gene symbol → proposed isoform groups (Ensembl, by 3' terminal exon) identify config → are the groups distinguishable by short reads? (k-mer uniqueness) extract Salmon quant.sf → per-donor ...

RNA is the means of translating the genetic code embedded in DNA into proteins, which serve as enzymes, transporters, signaling molecules, receptors, structural components, regulators, and ...

Summary: For years, scientists have used mRNA levels as a “blueprint” to estimate which proteins the brain is making. However, reveals that this blueprint is often misleading. Using a revolutionary ...

In a new study, Chinese researchers have discovered the previously unrecognized role of alternative splicing of the DOC2A gene in schizophrenia. The research was conducted by scientists led by LI Ming ...

Alternative splicing plays crucial roles in normal heart development and cardiac disease by influencing protein-coding sequences, functional domains, and molecular networks. However, a detailed ...

The ability to study transcript isoforms in detail could have a significant impact on our understanding of health and disease. However, most commonly, bulk sequencing is the selected method that only ...

Recently developed methods to predict three-dimensional protein structure with high accuracy have opened new avenues for genome and proteome research. We explore a new hypothesis in genome annotation, ...

Alternative splicing is an essential regulatory mechanism for gene expression in mammalian cells contributing to protein, cellular, and species diversity. In cancer, alternative splicing is frequently ...