Contributed by Howard Y. Chang; received November 19, 2024; accepted February 20, 2025; reviewed by Jellert Gaublomme and David A. Quigley The spatial organization of cells within tissues plays a ...

Among the assorted communities of brain cells contained within an 8 millimeter punch of cortex, scientists have captured what might reflect two pivotal microglial moments along the decades-long ...

This valuable study identifies and characterizes probe binding errors in a widely used commercial platform for spatial transcriptomics, discovering that at least 14 out of 313 genes in a human breast ...

Do you want to generate spatial transcriptomics data using your H&E images? We introduce DeepSpot, a novel deep-learning model that predicts spatial transcriptomics from H&E images. DeepSpot employs a ...

Abstract: The emergence of spatial transcriptomics has greatly advanced our understanding of disease mechanisms, identified novel therapeutic targets, and contributed to progress in personalized ...

Spatial EcoTyper is a versatile framework for identifying spatially distinct multicellular communities, termed spatial ecotypes, from single-cell spatial transcriptomics data. In addition, it provides ...

Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics are revolutionary techniques that offer unparalleled insights into cellular function and tissue architecture. scRNA-seq allows ...

Understanding how flower buds survive winter and resume growth in spring is crucial for fruit production, especially as climate change alters seasonal temperature patterns. This study maps the ...

“Illumina’s…presentations and product descriptions revealed a workflow that infringed on the ‘607, ‘138, ‘505, and ‘487 patents, 10x Genomics and Prognosys Biosciences argued.” On October 21, 10x ...

The liver is remarkable for its ability to regenerate after injury, yet when this process fails, acute liver failure (ALF) carries devastating outcomes. Traditional research methods, reliant on bulk ...