Researchers from the Cancer Science Institute of Singapore (CSI Singapore) at NUS have developed a new method that allows ...

The cancer genome is shaped by various mutational processes over its lifetime, stemming from exogenous and cell-intrinsic DNA damage, and error-prone DNA replication, leaving behind characteristic ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

This R package is served for analyzing OK-Seq data from original mapping bam file to count matrices, RFD calculation, and inititation/termination zone calling ...

Alphaherpesviruses hijack host epigenetic regulation by promoting HDAC1/2 nuclear export and degradation to activate the DNA damage response, revealing new antiviral therapeutic targets.

Leonard Zon, professor of stem cell and regenerative biology and Grousbeck Professor of Pediatrics at Harvard Medical School, has been awarded the 2026 March of Dimes Richard B. Johnston Jr., MD Prize ...

The tiny shell protecting the HIV virus resembles a slightly rounded ice cream cone, but there is nothing sweet about it. More than 40 million people worldwide live with AIDS because of this virus, ...

Harvard Medical School researchers have uncovered crucial insights into how an emerging class of antiviral drugs works. The discovery sheds light on an important tool for fighting drug-resistant ...

Scientists at the Center for Cell Dynamics, School of Biological and Behavioral Sciences, Queen Mary University of London, in collaboration with Carl Zeiss, have developed an innovative live-cell ...

The herpesvirus can manipulate our DNA with far more precision than previously thought. The virus condenses and changes the shape of our genetic material to hijack the host genes needed for ...

Extrachromosomal DNAs (ecDNAs) are circular DNA structures located in the nuclei of cells outside chromosomes. They were originally discovered in chromosome spreads of cells obtained from embryonal ...